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Testis GSCs, which are all mitotically active Wallenfang et al. I cannot thank you enough for this article! If lost GSCs were not replaced, testes in flies that are several weeks old would contain far fewer GSCs than testes in young flies, whereas in fact the number of GSCs per testis is only slightly reduced in old flies Wallenfang et al. The Girl Narrative as Degrading, Diminutive, or Spirited Rebellion? In the Drosophila testis niche, both GSCs and CySCs adhere to the hub, and their divisions are precisely oriented to balance self-renewal and differentiation. There is, it seems, a girl for nearly every kind of woman.
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To maintain tissue homeostasis throughout the lifetime of an organism, stem cells must be regulated in response to diverse physiological or pathological conditions. Although the precise mechanism is unclear, these results suggest that dedifferentiation is a regulated process that depends on local signals from the niche and not on chance encounters between differentiated cells and the hub. And, I have the highest respect for all girls. In Sas-4 mutants, which fail to replicate centrioles and therefore lack centrosomes, most GSCs still divide with spindles oriented perpendicular to the hub Riparbelli and Callaini,
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